Whitworth University Professor’s Research Could Offer New Hope for Those with Celiac Disease and Gluten Intolerance
Ojennus will use the Murdock Trust funding to investigate the structural biology of gluten-degrading enzymes. By studying how PepX interacts with calcium and its substrate, as well as how it works in combination with other enzymes, her research team hopes to develop a highly effective enzymatic approach to reducing gluten toxicity. The findings could lead to new oral enzyme supplements or food processing methods that make gluten-contaminated foods safer for those who suffer from gluten-related disorders.
“The short-term goal of our work is to understand how these enzymes interact with their substrates, but ultimately, we hope to provide real solutions for people who struggle with gluten intolerance,” Ojennus says. “By understanding the fundamental properties of PepX, we can work to optimize its ability to break down various proline-containing substrates, which can then be applied to gluten.”
Beyond its impact on public health, the project also has significant educational benefits, engaging undergraduate students in hands-on biochemical research. Students are directly involved in experimental design, data analysis and presenting their findings at scientific conferences, contributing to workforce development in STEM fields.
“This research has the potential to make a profound difference in the lives of individuals affected by gluten-related disorders,” Ojennus says. “By deepening our understanding of the underlying enzyme mechanisms, we are paving the way toward more effective and targeted treatment options. We are deeply grateful to the Murdock Charitable Trust for its generous support, which enables us to pursue this important and impactful work.”
The Celiac Disease Foundation estimates more than 700 million people throughout the world suffer from celiac disease and about 70 percent of Americans with the autoimmune disorder go undiagnosed.
About Whitworth University:
Located in Spokane, Wash., Whitworth is a private Christian liberal arts university affiliated with the Presbyterian church. The university, which has an enrollment of about 2,500 students, offers more than 100 undergraduate and graduate degree programs.
Contacts:
Trisha Coder, associate director of media relations, Whitworth University, (509) 777-4703 or tcoder@whitworth.edu.
